Methylisothiazolinone or MIT or MI, is a powerful biocide and preservative within the group of isothiazolinones, used in personal care products.
Current clinical data indicate that 100 ppm MI in cosmetic products is not safe for the consumer. For leave-on cosmetic products (including ‘wet wipes’), no safe concentrations of MI for induction of contact allergy or elicitation have been adequately demonstrated. For rinse-off cosmetic products, a concentration of 15 ppm (0.0015%) MI is considered safe for the consumer from the view of induction of contact allergy.
MI should not be used as an addition to a cosmetic product already containing MCI/MI. More frequent review of data (than suggested in SCCS/1482/12) to monitor sensitisation frequencies of MI and related isothiazolinone preservatives is recommended. This permits trends in consumers’ sensitisation to be
observed and timely intervention to be taken.
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